Are you ready to challenge the limits of existing immune/hepatic co-culture models? Join us in an exciting, hands-on role where you’ll help in advancing immune-mediated drug-induced liver injury (iDILI) in vitro models. At the intersection of pharmaceutical innovation and immune cell engagement, your work will address a high unmet need within the industry.

In this role, you’ll collaborate closely with scientists from Sanofi’s Investigative Toxicology group to further develop an advanced in vitro model of iDILI. Moving beyond traditional 2D models, you’ll test compounds in a medium-throughput liver microphysiological system (MPS) model that successfully recreates the interaction of monocytes and T-cells with hepatocytes and Kupffer cells to dissect the potential mechanism for iDILI.

Your goal? Co-culture monocyte-derived dendritic cells (moDCs) along with T cells and 3D liver spheroids to test a platform that can potentially detect iDILI. This is your chance to be at the forefront of validating a translational tool that could lead to deeper mechanistic understanding of novel therapies.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities:

• Collaborate with top-tier scientists to advance cutting-edge cell culture systems.

• Characterize and validate the iDILI model with an eye toward future drug development and safety assessments.

• Gain valuable experience with primary cell cultures, complex in-vitro models, HTS imaging (epifluorescence and confocal) and analysis, western blotting, gene expression, cytokine analysis, and in vitro barrier assessment assays.

About You

Must be permanently authorized to work in the U.S. and not require sponsorship of an employment visa (e.g., H-1B or green card) at the time of application or in the future. Students currently on CPT, OPT, or STEM OPT usually require future sponsorship for long term employment and do not meet the requirements for this program unless eligible for an alternative long-term status that does not require company sponsorship

Basic Qualifications:

• Currently enrolled and pursuing a master’s degree or PhD in biology, immunology, toxicology, or a related field at an accredited college or university with the expectation that you will complete your current degree by the Spring of 2028

• Must be able to relocate to the office location and work 40hrs/week, Monday-Friday, for the full duration of the co-op/internship

Preferred Qualifications:

• You’re a passionate researcher with a curious mind, eager to contribute and grow in a dynamic environment.

• You thrive in a collaborative, matrixed setting and bring strong written and verbal communication skills to the table.

• Experienced in primary mammalian cell culture, preferably immune cells and/or hepatocytes (required).

• Proficiency in confocal microscopy, flow cytometry, and cytokine analysis would be a plus.

If you're driven by curiosity, innovation, and the desire to make an impact in the world of drug development, this is the co-op experience for you. Join us in advancing iDILI models and developing tomorrow's therapies today!