2024 Intern - Data and Computational Sciences - Vaccines

RNA Bioinformatics Intern - Vaccine

In the race for the future of health – The Sanofi mRNA Center of Excellence (CoE)

At Sanofi, we chase the miracles of science, and we know mRNA has a role to play in the future of health. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines and treatments for more people faster than before.

That’s why we’re looking for bold, optimistic world-changers to join our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 450 dedicated employees, and focusing on implementing an integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.

Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology!

About the Opportunity

As an RNA Bioinformatics Intern, you will participate in a 4-month summer internship project in the areas of cheminformatics, bioinformatics, computational biology, and machine learning to the task of developing and implementing first-in-class and best-in-class computational solutions and models for screening, optimizing and evaluating lipid nanoparticles or RNA molecules for mRNA-based vaccines and therapeutics as part of the Data and Computational Science team in the mRNA CoE. This team brings end-to-end data integration and advanced analytics (pre-clinical, biomarkers, process development, CMC, clinical) in the mRNA CoE. Deploying and exploiting digital solutions (AI/machine learning, data, analytics) to integrate the full data value chain, extracting actionable information for a move to a full data driven strategy and decision-making process, to increase probability of success and to accelerate mRNA vaccines and therapeutics development and launch.

In this role you will:

• Collaborate with group experts in the development and execution of the scientific strategy and technical solutions to develop best-in-class mRNA vaccines and therapeutics

• Execute development of a project to deliver data and computational solutions for the integration of chemical, structural, and biological data to support data analytics and visualization

• Collaborate internally to develop scientific hypotheses and drive new scientific insights based on computational frameworks

• Develop computational pipelines (e.g., with Nextflow, Snakemake, or WDL) for a variety of Research and Development applications, with particular focus on in vitro and in vivo mRNA screening assays; next-generation sequencing (NGS) data and analysis; and the design, assembly, and quality control (QC) of pDNA and mRNA vaccines and therapeutics

• Create compelling visual representations of data and analytics results in support of presentation, communication, and decision-making needs for key stakeholders

• Provide support for experimental results using data analytic and/or machine learning techniques

• Maintain a well-documented, reusable codebase, and traceable model history

• Maintain awareness of latest developments in relevant fields, evaluate and apply as warranted

• Demonstrate good software engineering practices

• Proactively identify, assess, and internalize emerging technologies and methods

About you

• PhD or Masters student in Cheminformatics, Bioinformatics, Computational Chemistry, Computational Biology, Computer science, or related quantitative disciplines

• Have a basic understanding of different types of NGS assays

• Experience with NGS data/statistical analysis, with a preference for topics such as exploratory analysis and -omics data (e.g., ribosome profiling)

• Experience with machine learning, such as development of regression/classification models and deep learning models, is preferred but not required

• Familiarity with cloud and parallel computing

• Comfortable with one or more common data analysis and visualization platforms (e.g., R, RShiny, Python/pandas) and bioinformatics packages (Bioconductor, Biopython, etc.)

• Comfortable engaging with stakeholders from a variety of backgrounds and working collaboratively towards a common goal

• Adept at communication and adaptation

• Willing to train individuals and teams on your areas of expertise and on systems you build

• Fluency in English; Fluency in French is a plus

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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