mRNA – Scientist, Enzyme Engineer - Vaccine

mRNA – Scientist, Enzyme Engineer

Location – Waltham, MA

In the race for the future of health – The Sanofi MRNA Center of Excellence (CoE)

At Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines for more people faster than before.

That’s why we’re looking for bold, optimistic world-changers to join the team at our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 400 dedicated employees for it and using it as the foundation to implement integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.

Bring your ambition and optimism for the future to Sanofi. Join us

INTRO ABOUT THE POSITION

About the Opportunity

As an experienced Enzyme engineer, you will be responsible for designing and evaluating enzymes to improve mRNA manufacturing process and enable new RNA technologies.

KEY RESPONSIBILITIES FOR POSITION

About growing with us for winning with us

In this role you will:

• Work closely with team lead to develop and execute enzyme engineering projects to improve mRNA manufacturing platform and enable novel RNA technologies

• Develop enzyme assays for high throughput screening

• Assist in development of automated high throughput screening

• Design constructs and evaluate enzyme expression in microbial hosts at the lab scale

• Optimize enzyme purification process

• Collaborate on enzyme characterization

• Support tech transfer by preparing and sharing microbial strains, purified enzymes and protocols

• Handle complex protocols, assist in experimental design, data analysis, and summarize findings into technical reports

• Communicate effectively within the group and with other functional groups in the company

• Maintain professional, scientific, and ethical integrity

COMPETENCIES / REQUIREMENTS FOR POSITION

About you

• Ph.D. or M.S. (+5 years of industry experience) in Molecular biology, Synthetic biology, Biochemistry, Biotechnology, Biochemical engineering, or related field

• Deep knowledge in enzymology and enzyme engineering

• Hands-on experience in molecular cloning, PCR based mutagenesis, plasmid purification and analysis

• Hands-on experience in heterologous protein/enzyme expression in microbial hosts

• Hands on experience in protein purification (IMAC, IEX, SEC, HIC) and characterization (gel electrophoresis, immunoblotting)

• Experience with HPLC is a plus

• Familiarity to in vitro transcription (IVT) process and RNA characterization

• Expertise in measuring enzyme activity using ELISA and fluorescence-based assays

• Understanding of high throughput approaches for enzyme engineering

• Desire to work in a team-first, fast-paced environment, learn new skills, and to efficiently solve problems with a “can-do and will-do” attitude

• Attention to detail & meticulous record keeping

• Familiarity with molecular design tools and statistical analysis

Fixed hashtag

#mRNA

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#GD-SP
#LI-SP
PDN

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.