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Responsibilities

mRNA Analytical Development Process Support and Automation Scientist - Vaccine

Location: Waltham, MA

In the race for the future of health – The Sanofi MRNA Center of Excellence (CoE)

At Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines for more people faster than before.

That’s why we’re looking for bold, optimistic world-changers to join the team at our mRNA Center of Excellence. We’re investing €400m a year into the new center, hiring a team of 400 dedicated employees for it and using it as the foundation to implement integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.

Bring your ambition and optimism for the future to Sanofi.

Intro about the position

About the Opportunity

In order to strengthen the Biochemical and Biophysical group in R&D Analytical Sciences Department, Sanofi Pasteur is looking for a skilled and highly motivated individual to develop novel Bioassay methods and improve characterization of mRNA vaccines in development by working closely with the bioprocess development group.

Analytical Sciences Department has the overall responsibility to develop, qualify and validate robust analytical methods to support release and characterization testing of mRNA Drug Substances and Drug Products candidates in development.

Key responsibilities for position

About growing with us for winning with us

In this role you will be responsible for, not limited, to the following activities.

Develop high throughput methods using automation platforms to support process and product development, including process optimization and characterization, as well as in-process control.
Support process analytical technology implementation.
Follow up with industry trend and identify advanced technology for process support applications.
Provide technology transfer support as needed.
Ensure timely completion of assignments and deliverables.
Independently design and execute complex experiments.
Author method development and investigation reports.
Manage assay testing at CROs if required, support investigation from different mRNA programs.
Participate internal non-GMP and GMP lab set up and product release and stability testing and investigations, when needed.
Supervise and train junior scientists.

Relevant Qualifications & Capabilities

PhD or MSc/Analytical Chemistry, Chemical Engineering, Biochemistry, or related sciences
PhD with 3+ years or MSc with at least 8+ years pharma/biotech industry experience, skilled in bioassays
Expertise in some of the techniques, including but not limited to high throughput sequencing, kinetic assays, ELISA, qPCR, ddPCR, Ribogreen, chromatography, LC-MS, capillary electrophoresis, etc.
Experienced in automation and high throughput method development and troubleshooting, hands-inexperience with Hamilton, Biomek or similar automation platform.
Ability to perform complex method development and propose appropriate method improvement.
Knowledge of nucleic acid/oligonucleotides chemistry and standard analytical methods of these molecules.
Proven capability of evaluating/developing new technologies
Experienced in working with highly technical projects with reactivity.
Excellent verbal and written communication skills.

#mRNA

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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#MRNA

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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