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mRNA -Scientist - Engineer Drug Product Development - Vaccine



Waltham, MA, USA
Posted on Wednesday, July 12, 2023
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mRNA -Scientist - Engineer Drug Product Development - Vaccine

Waltham, Massachusetts

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"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders


In the race for the future of health– The Sanofi mRNA Center of Excellence (CoE)

At Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines for more people faster than before.

That’s why we’re looking for bold, optimistic world-changers to join the team at our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 400 dedicated employees for it and using it as the foundation to implement integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.

Bring your ambition and optimism for the future to Sanofi.

About this opportunity:

As drug product development engineer, you will participate in process optimization and scale-up of mRNA-lipid nanoparticle (LNP) drug products for therapeutic (gene medicine) and vaccine modalities.

In this role you will….

  • Lead and support the optimization and scale-up of Bulk Drug Product (BDP) formulation and Final Drug Product (FDP) processes encompassing a wide range of different DS and multi-component LNPs

  • Perform routine and complex analytical methods with minimal supervision

  • Keep detailed records using an electronic laboratory notebook

  • Present experimental results to group and CMC teams as needed

  • Critical thinking and analysis of data will be central to all aspects of this position

  • Design, procure, and maintain equipment in the Process Development lab and pilot plant

  • Produce materials that is representative of cGMP material and suitable for nonclinical studies including GLP toxicology studies

  • Assist with preparation of technical reports and presentations to clearly communicate scientific findings as needed


  • BS/MS/PhD degree, preferably in Chemical Engineering, Pharmaceutical Sciences or in a similar field is required

  • BS & 5+ years’ experience / MS & 3+ years’ experience / PhD & 0 – 2 years’ experience working in a process development or tech transfer environment

  • Candidate with process development knowledge is highly desirable

  • Experience with LNP formulations of mRNA/siRNA would be beneficial

  • Previous work with mRNA (handling/isolation/quantification/characterization) is desired

  • Knowledge of mRNA and LNP characterization methods preferred


  • Capable of working in a collaborative team environment both within group and on interdisciplinary teams

  • Desire to work in a fast-paced environment

  • Excellent organizational and communication skills

  • Strong analytical and problem-solving skills

  • Ability to present findings to a diverse scientific group in a clear and concise manner is necessary

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.




At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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