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Senior Scientist, Structural Biology



Cambridge, MA, USA
Posted on Wednesday, May 24, 2023

Senior Scientist, Structural Biology

Cambridge, Massachusetts


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Senior. Scientist - U.S. IDD structural biology

We are looking for a highly motivated scientist to join our structural biology group at Sanofi in Cambridge MA. As a key member of our dynamic team, you will be responsible for determining critical structural biology data through both cryo-electron microscopy and x-ray crystallography; actively pursuing solutions for unmet medical needs in diverse therapeutic areas and collaborating with multidisciplinary teams within Sanofi in Cambridge, US, Frankfurt, Germany and Paris, France. The successful candidate will excel in a fast-paced, highly diverse discovery environment, will have a strong focus on scientific rigor, have proven success in organized and independent work, and an exceptional attention to detail. Applicants who are passionate about structural biology are encouraged to apply.

Candidate profile:

  • CryoEM expert scientist that can independently design and carry out EM experiments and interpret results (sample preparation, data collection, data processing and solving structures). Analyze interactions and propose structure-based improvements for small-molecule drug discovery. Enable building state-of-the art technologies in related areas to enhance research activities.

  • Work closely with Sanofi digital to automate CryoEM data collection processes to evaluate samples in medium-throughput manner. Python or other programming languages for building pipelines for data collection and processing is a plus.

  • Share responsibility for maintaining the Glacios cryo-electron microscope (beam alignment, calibration, cryo-cycling, etc.).

  • Expertise with all related softwares (CryoSparc, SerialEM, Relion, cisTEM, Chimera, Eman2, Coot, phenix, ccp4 suite etc.).

  • Provide expertise to project teams pursuing different drug modalities at Sanofi.

  • Manage and deliver on projects in a timely fashion.

  • Train new users on finer aspects of CryoEM grid preparation and data collection when necessary.

  • Experience in X-ray crystallography is a strong plus. The candidate will be expected to train to support this area in case of no prior experience.

  • Experience in expression and purification strategies using bacterial, insect, and mammalian hosts and membrane protein purification. The candidate should be capable of purifying protein for the structural biology group when needed.

  • Experience in biophysical characterization (SPR, DSF, MST etc.) is a plus.

  • Have excellent communication skills. Should be able to clearly articulate data, project strategies both internally and externally.


  • PhD with 3+yrs of postdoctoral and/or industry experience in Structural Biology, Biophysics, Protein Biochemistry or related discipline.

  • Strong experience in cryo-EM is required.

  • The ideal candidate should be detail-oriented, organized and demonstrate good lab practices.

  • Must be a collaborative team player with strong communication skills.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.


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