Senior Scientist, Structural Biology
Senior Scientist, Structural Biology
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Senior. Scientist - U.S. IDD structural biology
We are looking for a highly motivated scientist to join our structural biology group at Sanofi in Cambridge MA. As a key member of our dynamic team, you will be responsible for determining critical structural biology data through both cryo-electron microscopy and x-ray crystallography; actively pursuing solutions for unmet medical needs in diverse therapeutic areas and collaborating with multidisciplinary teams within Sanofi in Cambridge, US, Frankfurt, Germany and Paris, France. The successful candidate will excel in a fast-paced, highly diverse discovery environment, will have a strong focus on scientific rigor, have proven success in organized and independent work, and an exceptional attention to detail. Applicants who are passionate about structural biology are encouraged to apply.
CryoEM expert scientist that can independently design and carry out EM experiments and interpret results (sample preparation, data collection, data processing and solving structures). Analyze interactions and propose structure-based improvements for small-molecule drug discovery. Enable building state-of-the art technologies in related areas to enhance research activities.
Work closely with Sanofi digital to automate CryoEM data collection processes to evaluate samples in medium-throughput manner. Python or other programming languages for building pipelines for data collection and processing is a plus.
Share responsibility for maintaining the Glacios cryo-electron microscope (beam alignment, calibration, cryo-cycling, etc.).
Expertise with all related softwares (CryoSparc, SerialEM, Relion, cisTEM, Chimera, Eman2, Coot, phenix, ccp4 suite etc.).
Provide expertise to project teams pursuing different drug modalities at Sanofi.
Manage and deliver on projects in a timely fashion.
Train new users on finer aspects of CryoEM grid preparation and data collection when necessary.
Experience in X-ray crystallography is a strong plus. The candidate will be expected to train to support this area in case of no prior experience.
Experience in expression and purification strategies using bacterial, insect, and mammalian hosts and membrane protein purification. The candidate should be capable of purifying protein for the structural biology group when needed.
Experience in biophysical characterization (SPR, DSF, MST etc.) is a plus.
Have excellent communication skills. Should be able to clearly articulate data, project strategies both internally and externally.
PhD with 3+yrs of postdoctoral and/or industry experience in Structural Biology, Biophysics, Protein Biochemistry or related discipline.
Strong experience in cryo-EM is required.
The ideal candidate should be detail-oriented, organized and demonstrate good lab practices.
Must be a collaborative team player with strong communication skills.
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