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mRNA Senior Scientist, Plasmid Production - Vaccines



Waltham, MA, USA
Posted on Friday, May 12, 2023

mRNA Senior Scientist, Plasmid Production - Vaccines

Waltham, Massachusetts


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"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders


mRNA Senior Scientist - Plasmid Production - Vaccines

In the race for the future of health – The Sanofi mRNA Center of Excellence (CoE)

At Sanofi, we chase the miracles of science, and we know mRNA has a role to play in the future of health. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines and treatments for more people faster than before. That’s why we’re looking for bold, optimistic world-changers to join our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 400 dedicated employees, and focusing on implementing an integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams. Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology.

Opportunity and Responsibilities

We are seeking a highly motivated and scientifically rigorous individual to join the Plasmid Production Pilot team as a Senior Scientist. You will focus on optimization and scale-up of a robust pDNA production process through fermentation, cell lysis extraction, linearization, and purification for preclinical linearized plasmid DNA production, with the ultimate goal of transferring at-scale methods to either the internal or external manufacturing teams for mRNA drug substance manufacturing team with applications towards vaccine development.

  • Develop, evaluate, and implement new biology and purification technology and optimize existing techniques and workflows.

  • Lead in the execution and optimization of plasmid production, problem solving.

  • Function in highly collaborative cross functional teams.

  • Design and execute decision-quality research; prepare/draft SOPs, technical reports, batch record, and presentations to management and other stakeholders.

  • Work independently, pro-actively, and be an impactful contributor to project teams. Mentor team members as needed.

  • This will be primarily a lab-based position.


  • BS with 7+ years, MS with 4+ years or Ph.D. with 2+ years of relevant industrial experience in a related field (e.g. cell or molecular biology, biochemistry, chemical or biomedical engineering, biotechnology) for Senior Scientist role.

  • Demonstrated success in scale-up and hands-on experience in plasmid manipulation, fermentation and process optimization.

  • Hands-on experience with small and pilot scale reactor (5-30L) with preferable experience of single-use fermenter.

  • DNA extraction experience including bacterial culture, plasmid DNA purification methodologies including alkali lysis, chromatography separation (anion exchange, hydrophobic interaction) and buffer exchange methods such as TFF are preferred.

  • Expertise in equipment setup, process troubleshooting and maintenance and experience in GLP environment is advantageous.

  • Works collaboratively within group for improved operational excellence as well as within interdisciplinary teams.

  • Desire to work in a team-first, fast-paced environment, learn new technologies and skills, and to efficiently solve problems.

  • Excellent organizational and communication skills.

  • Attention to detail & meticulous record keeping.

  • Analyze, interpret, and summarize results in reports and presentations.

  • Demonstrate continuous growth in depth and breadth of personal scientific knowledge and understanding of strategic goals of group, team, and company.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.


At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.


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