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Senior Associate Scientist, Hybridoma and B Cell Antibody Discovery



Cambridge, MA, USA
Posted on Friday, November 10, 2023

What You Will Achieve

Biomedicine Design’s Endogenous Antibody Discovery Group is seeking a Senior Associate Scientist to support hybridoma-based antibody discovery projects and related workflows. The role requires joining other group members to carry out therapeutic antibody discovery campaigns employing immunization of rodents and hybridoma generation, in coordination with other discovery methods such as FACS and immune library generation and panning. In particular, the role requires carrying out all established workflows associated with hybridoma-based antibody discovery, including selection of rodents (wildtype and transgenic) as hosts for immunization; immunizations (protein, cell-based and genetic); evaluation of serum responses by ELISA; electro-cell fusion; hybridoma culture and screening; and VH-VL molecular cloning. Finally, the role requires evaluation and integration of new technologies related to hybridoma generation and therapeutic antibody discovery, in coordination with other group members.

How You Will Achieve It

  • End-to-end support of hybridoma campaigns for lead therapeutic antibody discovery.

  • Monitoring and maintaining stocks of reagents required for hybridoma workflows.

  • Preparation and presentation of reports summarizing outputs of hybridoma campaigns.



  • BSc degree with 3+ years of experience with wet lab and working full time in a university or industry lab setting OR Masters Degree with 0+ years of experience with wet lab experience.

  • Experience with primary cell culture and aseptic techniques.

  • Experience with molecular biology techniques, including PCR.

  • Experience working with rodents, in particular mice.

  • Excellent communication skills, written and oral.


  • Experience with flow cytometry.

  • Experience with laboratory automation.

  • Experience working with hybridomas.


  • Lifting, sitting, standing, walking, bending, ability to do math and calculations, ability to perform data analysis.

Work Location Assignment: On Premise. On Premise colleagues work in a Pfizer site because it’s needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.

Other Job Details

Last Date to Apply: December 7th, 2023.

The annual base salary for this position ranges from $62,800.00 to $104,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development